Reina consists of needle and Polydioxanone(PDO) or Poly-L-Lactic Acid(PLLA) thread. Reina is intended for being inserted into skin, causing artificial wound. It induces healing effect of the body itself followed by tightening and lifting effect. The safety of the threads are verified as they have been used sewing wound in normal hospitals since 2001. Also they are biocompatible and biodegradable.