HappyCross 16mg/ml (1×2.2ml)

HAppyCross™ is a cross-linked hyaluronic acid gel (IPN-Like technology). Cross-linking:

• Ensures a gel-like rheological behaviour, maximizing then the mechanical properties of hyaluronic acid.

• Increases the residence time of the gel in the joint cavity, preventing biodegradation from free radicals and enzymes.

Compared to the classic cross-linking technique, the IPN-Like technology, or InterPenetrated Cross-linked Networks, involves combining, inserting one into another, two monophasic hyaluronic acid networks previously purified and cross-linked which are mechanically independent. Interpenetration of Cross-linked Networks:

• Optimizes the density of the chemical bonds while minimizing the use of reticulating agent (BDDE) within the monophasic gel, ensuring a longer-lasting effect of the product.

• Preserves the partial independence of the inter-penetrated networks and guarantees the gel is supple and easy to inject into the joint.

HAppyCross™ also contains high concentration of mannitol (77mg/syringe).

Long-lasting effect: Mannitol is an anti-oxidant which protects hyaluronic acid chains from free radicals and limits their degradation, increasing then their residence time in the joint cavity.

Analgesic effect: Due to its free radical scavenging properties, mannitol also ensures local analgesic effect.

Stabilizer: because it is a thermal stabilizer, mannitol allows HAppyCross™ to guarantee a stability of its rheological properties all along its storage.